郭锐华(副教授)

发布者:刘源发布时间:2021-04-23浏览次数:10

郭锐华,副教授,以药食同源植物为研究基础,通过活性追踪的方法,找到活性成分,研究其功效;从海洋微生物的代谢产物中发现具有活性的天然产物,并进行活性评价,对活性较好的化合物进一步进行结构修饰和结构简化,从而发现较好的活性化合物,研究其对疾病的影响,以降低疾病的发生率。

联系方式:

电话:021-61900387

E-mail:rhguo@shou.edu.cn 


 

教育经历

2008.09—2011.07,中国科学院昆明植物研究所,药物化学,博士,导师:周俊院士、陈纪军研究员

2004.09—2007.06,汕头大学,工业催化,硕士,导师:方奕文教授

2000.09—2004.06,郑州大学,化学工程与工艺,学士

工作经历

2014.08—至今,上海海洋大学,食品学院

2011.07—2014.07,中国人民解放军第二军医大学,药学院,博士后,合作导师:张卫东教授

教学

目前承担的课程情况:

课程名称           学时    授课对象

药物化学            48     本科生

药物合成反应        48     本科生

药物合成反应试验    32     本科生

高等药物化学        16      研究生

科研


项目名称

起止时间

项目来源

本人承担任务

1

ZSK植物中抗肿瘤活性成分的研究

2018. 04-2019. 12

企业

主持

2

食品学院中青年人才培育项目

 

2018. 04-2019. 12

食品学院 

主持

3

海洋双吲哚纤溶化合物的结构修饰及其构效关系研究

2016. 01-2018. 12

国家自然科学基金青年项目

主持

4

基于毒理学评价的溶血栓药物先导化合物FGFC1临床前研究

2014. 10-2017. 09

上海市创新行动计划

参与

5

印度洋鱼类胶原蛋白生物医学材料应用特性的研究

2016. 01-2018. 12

上海市科委科技创新行动计划

参与

6

海洋微生物代谢产物的分离、衍生化及纤溶活性研究

2015. 01-2016. 12

上海市高校青年教师培养资助计划

主持

7

海洋溶栓先导化合物FGFC2结构修饰与构效关系的研究

2014. 09-2016. 09

上海海洋大学博士科研启动基金

主持

8

抗炎的倍半萜内酯IF-24的全合成及其构-效关系初探

2012. 01-2013. 12

中国博士后科学基金面上项目

主持

9

国家杰出青年科学基金

2011/01-2014/12

国家杰出青年科学基金

参与

 

[1] Yinan Wang †, Hui Chen†, Ruilong Sheng , Zhe Fu, Junting Fan, Wenhui Wu, Qidong Tu,* Ruihua Guo*, Synthesis and Bioactivities of Marine Pyran-Isoindolone Derivatives as Potential Antithrombotic Agents, Marine Drugs 2021, 19, 218.

[2] Yinan Wang, Jiangming Wang, Zhe Fu, Ruilong Sheng, Wenhui Wu, Junting Fan, Ruihua Guo,* Syntheses and evaluation of daphnetin derivatives as novel G protein-coupled receptor inhibitors and activators, Bioorganic Chemistry 2020, 104, 104342.

[3] Jiangming Wang, Silei Lu, Ruilong Sheng, Junting Fan, Wenhui Wu and Ruihua Guo,* Structure-Activity Relationships of Natural and Synthetic Indole-Derived Scaffolds as α-Glucosidase Inhibitors: A Mini-Review, Mini-Reviews in Medicinal Chemistry 2020, 20, 1791-1818.

[4] Changhao Bian, Jiangming Wang, Xinyi Zhou, Wenhui Wu,* and Ruihua Guo*. Recent Advances on Marine Alkaloids from Sponges, Chemistry & Biodiversity 2020, 17, e2000186.

[5] Silei Lu, Jiangming Wang, Ruilong Sheng, Yiwen Fang, and Ruihua Guo*, Novel Bioactive Polyketides Isolated from Marine Actinomycetes: An Update Review from 2013 to 2019, Chemistry & Biodiversity 2020, 17, e2000562.

[6] Yang Zhang, Kai Cheng, Bingwei Xu, Junfeng Shi, Jun Qiang, Shunjin Shi, Yuanqin Yi, Hongxia Li, Tengchuan Jin, Ruihua Guo, Yadi Wu, Zeyi Liu, Xiaowei Wei*, Jian-An Huang* and Xiuwei H. Yang*, Epigenetic Input Dictates the Threshold of Targeting of the Integrin-Dependent Pathway in Non-small cell Lung Cancer. Frontiers in Cell and Developmental Biology 2020, 8, 652.

[7] Jiangming Wang, Changhao Bian, Yinan Wang, Quan Shea, Bin Bao, Junting Fan, Aixue Zuo*, Wenhui Wu*, Ruihua Guo*. Syntheses and bioactivities of songorine derivatives as novel G proteincoupled receptor antagonists, Bioorganic & Medicinal Chemistry, 2019, 27, 1903.

[8] Jiangming Wang, Siyuan Su, Shangzhe Zhang, Shiyang Zhai, Ruilong sheng, Wenhui Wu, Ruihua Guo*. Structure-activity relationship of α-santonin derivatives with diverse bioactivities: a mini-review, European Journal of Medicinal Chemistry, 2019, 175, 215.

[9] Ruihua Guo†, Dong Duan†, Shaotong Hong, Yu Zhou, Fang Wang, ShujunWang, Wenhui Wu*, Bin Bao*. A Marine Fibrinolytic Compound FGFC1 Stimulating Enzymatic Kinetic Parameters of A Reciprocal Activation System Based on a Single Chain Urokinase-type Plasminogen Activator and Plasminogen, Process Biochemistry2018, 68, 190.

[10] Ruihua Guo, Chengxin Guo, Dan He, Dake Zhao, Yong Shen*. Two New C-19-Diterpenoid Alkaloids with Anti-inflammatory Activity from Aconitum iochanicum. Chinese Journal Chemistry, 2017, 35, 1644.

[11] Qinghong Kong, Ting Wu, Yingqi Tang, Lemin Xiong, Hong Liu, Junhao Zhang, Ruihua Guo*, Feng Zhang*. Improving Thermal and Flame Retardant Properties of Epoxy Resin with Organic NiFe-Layered Double Hydroxide-Carbon Nanotubes Hybrids. Chinese Journal Chemistry2017, 35, 1875.

[12] Ruihua Guo†, Yiting Zhang†, Dong Duan, Qiang Fu, Xiangyu Zhang, Xiaowei Yu, Shujun Wang, Bin Bao*, Wenhui Wu*. Fibrinolytic Evaluation of Compounds Isolated from a Marine Fungus Stachybotrys longispora FG216. Chinese Journal Chemistry, 2016, 34, 1194.

[13] Ge Wang; Wenhui Wu; Quangang Zhu; Shiqing Fu; Xiaoyu Wang; Shaotong Hong; Ruihua Guo*; Bin, Bao* Identification and Fibrinolytic Activity of an Indolone Derivative Isolated from a Rare Marine Fungus Stachybotrys longispora FG216. Chinese Journal Chemistry2015, 33, 1089–1095.

[14] Rui-Hua Guo, Quan Zhang, Yun-Bao Ma, Xiao-Yan Huang, Jie Luo, Xue-Mei Zhang, Jun Zhou, Ji-Jun Chen. Synthesis of Hemslecin A Derivatives: A New Class of Hepatitis B Virus Inhibitors. Bioorganic & Medicinal Chemistry Letters, 2013, 23, 1201–1205.

[15] Rui-Hua Guo, Quan Zhang, Yun-Bao Ma, Jie Luo, Chang-An Geng, Li-Jun Wang, Xue-Mei Zhang, Jun Zhou, Zhi-Yong Jiang, Ji-Jun Chen. Structure–activity Relationships Study of 6-Chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl) quinolin-2(1H)-one Derivatives as Novel Non-nucleoside Anti-hepatitis B Virus Agents. European Journal of Medicinal Chemistry, 2011, 46, 307319.

[16] Rui-Hua Guo, Quan Zhang, Yun-Bao Ma, Jie Luo, Li-Jun Wang, Chang-An Geng, Xue-Mei Zhang, Jun Zhou, Zhi-Yong Jiang, Ji-Jun Chen. Synthesis and Biological Assay of 4-Aryl-6-chloro-quinoline Derivatives as Novel Non-nucleoside Anti-HBV Agents. Bioorganic & Medicinal Chemistry, 2011, 19, 1400–1408.

[17] Hao Chen, Yun-Bao Ma, Xiao-Yan Huang, Chang-An Geng, Yong Zhao, Li-Jun Wang, Rui-Hua Guo, Wen-Juan Liang, Xue-Mei Zhang, Ji-Jun Chen. Synthesis, Structure-activity Relationships and Biological Evaluation of Dehydroandrographolide and Andrographolide Derivatives as Novel Anti-hepatitis B virus Agents. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 2353–2359.

[18] Chang-An Geng, Li-Jun Wang, Rui-Hua Guo, Ji-Jun Chen. Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents. Mini-Reviews in Medicinal Chemistry, 2013, 13, 749–776.

[19] Li-Jun Wang, Chang-An Geng, Yun-Bao Ma, Xiao-Yan Huang, Jie Luo, Hao Chen, Rui-Hua Guo, Xue-Mei Zhang, Ji-Jun Chen. Synthesis, Structure-activity Relationships and Biological Evaluation of Caudatin Derivatives as Novel Anti-hepatitis B Virus Agents. Bioorganic & Medicinal Chemistry, 2012, 20, 2877–2888.

[20] Chang-An Geng, Li-Jun Wang, Xue-Mei Zhang, Yun-Bao Ma, Xiao-Yan Huang, Jie Luo, Rui-Hua Guo, Jun Zhou, Yong Shen, Ai-Xue Zuo, Zhi-Yong Jiang, Ji-Jun Chen. Anti-Hepatitis B Virus Active Lactones from the Traditional Chinese Herb: Swertia mileensis. Chemistry: A European Journal, 2011, 17, 3893–3903.

[21] Li-Jun Wang, Chang-An Geng, Rui-Hua Guo, Quan Zhang, Ji-Jun Chen. Natural Products as Novel anti-HBV Agents. Asian Chemistry Letter, 2011, 15, 271–282.

[22] Quan Zhang, Zhi-Yong Jiang, Jie Luo, Yun-Bao Ma, Ji-Feng Liu, Rui-Hua Guo, Xue-Mei Zhang, Jun Zhou, Wei Niu, Fei-Fe Du, Li Li, Chuan Li, Ji-Jun Chen. Anti-HBV Agents. Part 3: Discovery and Preliminary Structure-activity Relationships of tetra-Acetyl-alisol A as a Highly Potent Anti-hepatitis B Virus Inhibitor. Bioorganic & Medicinal Chemistry Letters, 2009, 19, 6659–6665.

[23] Quan Zhang, Zhi-Yong Jiang, Jie Luo, Ji-Feng Liu, Yun-Bao Ma, Rui-Hua Guo, Xue-Mei Zhang, Jun Zhou, Ji-Jun Chen. Anti-HBV Agents. Part 2: Synthesis and in vitro Anti-hepatitis B Virus Activities of Alisol A Derivatives. Bioorganic & Medicinal Chemistry Letters, 2009, 19, 21482153. 

申请专利

[1] 郭锐华,段东,钱士云,包斌,张朝燕,吴文惠. 极地海洋微生物产生的几种溶栓化合物的制备方法及用途,ZL201710823626.6.

[2] 吴文惠,郭锐华,姜胜男,段东,包斌,周文靖. 喃骈吲哚化合物及其制备方法和应用. 发明专利. 申请时间:2017年 授权时间2019年. ZL201710568099.9.

[3] 郭锐华,吴文惠,包斌,张依婷,王格,张朝燕,一种吡喃骈吲哚化合物及其制备方法和应用,ZL201510486160.6

[4] 陈纪军,郭锐华,江志勇,罗杰,马云保,周俊,张雪梅. 中国专利:2-(1H)喹啉酮衍生物,其药物组合物及其用途. 授权号:ZL 201010186032.7.

[5] 陈纪军,郭锐华, 马云保,江志勇,黄晓燕,罗杰,周俊,张雪梅. 中国专利:喹啉衍生物,其药物组合物及其用途. 授权号:ZL 201010548975.X.

获奖情况

2019年度海洋科学技术奖,一等奖

2019年获得上海海洋科技术奖,二等奖

2018年获得国家海洋局海洋科学技术奖,二等奖

2015年获得上海海洋大学教学成果,二等奖