郭锐华

发布者:张水晶发布时间:2017-08-31浏览次数:13


 

       郭锐华,女,2011年毕业于中国科学院昆明植物研究所,获药物化学专业博士学位,师从周俊院士、陈纪军研究员。随后在第二军医大学药学院,博士后研究工作,合作导师张卫东教授。2014年8月到上海海洋大学食品学院任教。主要研究方向:从海洋微生物代谢产物中发现活性天然产物,并对天然产物进行深入的结构与活性的研究,开发具有自主知识产权的药物。


 

联系方式:15692162383

 电话:021-61900387

 E-mail:rhguo@shou.edu.cn


 一、教学:

 目前承担的本科生课程情况:

 课程名称                    学时     授课对象

 药物化学            48     本科生

 药物合成            48     本科生

 药物合成反应试验    24     本科生



 

二、科研:


项目名称  

起止时间  

项目来源  

本人承担任务


海洋双吲哚纤溶化合物的结构修饰及其构效关系研究

2016.01-2018.12

国家自然科学基金青年项目

主持


印度洋鱼类胶原蛋白生物医学材料应用特性的研究

2016.01-2018.12

上海市科委科技创新行动计划

参与

3.

海洋微生物代谢产物的分离、衍生化及纤溶活性研究

2015.01-2016.12

上海市高校青年教师培养资助计划

主持

4.

海洋溶栓先导化合物FGFC2结构修饰与构效关系的研究

2014.09-2016.09

上海海洋大学博士科研启动基金

主持

5.

抗炎的倍半萜内酯IF-24的全合成及其构-效关系初探

2012.01-2013.12

中国博士后科学基金面上项目

主持

6.

 中药药效物质


2011.01-2014.12

国家杰出青年科学基金

参与

7.

 抗HBV活性化合物HB-103衍生物合成与活性研究


2008.01-2010.12

国家自然科学基金面上项目

参与


 三、发表论文:


  1. Ruihua Guo,† Yiting Zhang,† Dong Duan, Qiang Fu, Xiangyu Zhang, Xiaowei Yu, Shujun Wang, Bin Bao* and Wenhui Wu*,Fibrinolytic Evaluation of Compounds Isolated from a MarineFungus Stachybotrys longispora FG216. Chin. J. Chem.2016, 34, 1194–1198.  

  2. Ge Wang,† Wenhui Wu,† Quangang Zhu, Shiqing Fu, Xiaoyu Wang,Shaotong Hong, Ruihua Guo* and Bin Bao*Identification and Fibrinolytic Activity of an Indolone Derivative Isolated from a Rare Marine Fungus Stachybotrys longispora FG216. Chin. J. Chem.2015, 33, 1089–1095.  

  1. Rui-Hua Guo, Quan Zhang, Yun-Bao Ma, Xiao-Yan Huang, Jie Luo, Xue-Mei Zhang, Jun Zhou, Ji-Jun Chen. Synthesis of Hemslecin A Derivatives: A New Class of Hepatitis B Virus Inhibitors. Bioorganic & Medicinal Chemistry Letters, 2013, 23, 1201–1205.

  2. Rui-Hua Guo,Quan Zhang, Yun-Bao Ma, Jie Luo, Chang-An Geng, Li-Jun Wang, Xue-Mei Zhang, Jun Zhou, Zhi-Yong Jiang, Ji-Jun Chen. Structure–activity Relationships Study of 6-Chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl) quinolin-2(1H)-one Derivatives as Novel Non-nucleoside Anti-hepatitis B Virus Agents. EuropeanJournal of Medicinal Chemistry, 2011, 46, 307–319.

  3. Rui-Hua Guo,Quan Zhang, Yun-Bao Ma, Jie Luo, Li-Jun Wang, Chang-An Geng, Xue-Mei Zhang, Jun Zhou, Zhi-Yong Jiang, Ji-Jun Chen. Synthesis and Biological Assay of 4-Aryl-6-chloro-quinoline Derivatives as Novel Non-nucleoside Anti-HBV Agents. Bioorganic & Medicinal Chemistry, 2011, 19, 1400–1408.  

  4. Hao Chen, Yun-Bao Ma, Xiao-Yan Huang, Chang-An Geng, Yong Zhao, Li-Jun Wang, Rui-Hua Guo, Wen-Juan Liang, Xue-Mei Zhang, Ji-Jun Chen. Synthesis, Structure-activity Relationships and Biological Evaluation of Dehydroandrographolide and Andrographolide Derivatives as Novel Anti-hepatitis B virus Agents. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 2353–2359.

  5. Chang-An Geng, Li-Jun Wang, Rui-Hua Guo, Ji-Jun Chen. Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents. Mini-Reviews in Medicinal Chemistry, 2013, 13, 749–776.

  6. Li-Jun Wang, Chang-An Geng, Yun-Bao Ma, Xiao-Yan Huang, Jie Luo, Hao Chen, Rui-Hua Guo, Xue-Mei Zhang, Ji-Jun Chen. Synthesis, Structure-activity Relationships and Biological Evaluation of Caudatin Derivatives as Novel Anti-hepatitis B Virus Agents. Bioorganic & Medicinal Chemistry, 2012, 20, 2877–2888.

  7. Chang-An Geng, Li-Jun Wang, Xue-Mei Zhang, Yun-Bao Ma, Xiao-Yan Huang, Jie Luo, Rui-Hua Guo, Jun Zhou, Yong Shen, Ai-Xue Zuo, Zhi-Yong Jiang, Ji-Jun Chen. Anti-Hepatitis B Virus Active Lactones from the Traditional Chinese Herb: Swertia mileensis. Chemistry: A European Journal, 2011, 17, 3893–3903.  

  8. Li-Jun Wang, Chang-An Geng, Rui-Hua Guo, Quan Zhang,Ji-Jun Chen.Natural Products as Novel anti-HBV Agents. Asian Chemistry Letter, 2011, 15, 271–282.

  9. Quan Zhang, Zhi-Yong Jiang, Jie Luo, Yun-Bao Ma, Ji-Feng Liu, Rui-Hua Guo, Xue-Mei Zhang, Jun Zhou, Wei Niu, Fei-Fe Du, Li Li, Chuan Li, Ji-Jun Chen. Anti-HBV Agents. Part 3: Discovery and Preliminary Structure-activity Relationships of tetra-Acetyl-alisol A as a Highly Potent Anti-hepatitis B Virus Inhibitor. Bioorganic & Medicinal Chemistry Letters, 2009, 19, 6659–6665.

  10. Quan Zhang, Zhi-Yong Jiang, Jie Luo, Ji-Feng Liu, Yun-Bao Ma,Rui-Hua Guo, Xue-Mei Zhang, Jun Zhou, Ji-Jun Chen. Anti-HBV Agents. Part 2: Synthesis and in vitro Anti-hepatitis B Virus Activities of Alisol A Derivatives. Bioorganic & Medicinal Chemistry Letters, 2009, 19, 2148–2153.

 

四、申请专利

  1.  郭锐华,段东,钱士云,张依婷,王格,包斌,吴文惠. 一种吡喃骈吲哚乙酰化衍生物及其制备方法和应用. 申请号:201710172939.X.

  2.  郭锐华,吴文惠,包斌,张依婷,王格,张朝燕. 一种吡喃骈吲哚类化合物及其制备方法和应用. ZL 201510486160.6.

  3.  陈纪军,郭锐华,江志勇,罗杰,马云保,周俊,张雪梅. 中国专利:2-(1H)喹啉酮衍生物,其药物组合物及其用途. 授权号:ZL 201010186032.7.

  4.  陈纪军,郭锐华, 马云保,江志勇,黄晓燕,罗杰,周俊,张雪梅. 中国专利:喹啉衍生物,其药物组合物及其用途. 授权号:ZL 201010548975.X.